Pyelonephritis is most often the cause of a bladder infection which travels up into the kidneys of a cat. An advanced infection elsewhere in the body (for example, periodontal disease) can also be the result. If the infection is acute, signs will usually include bloody urine, vomiting, and fever. The cat may also develop a hunched posture due to the kidneys being very painful. If the infection is chronic, listlessness and weight loss may appear. The cat will already be in kidney failure at this point.

For the successful treatment of pyelonephritis, an early diagnosis is vital. Fluid therapy may be administered. Antibiotics will also usually be prescribed, along with a specific dietary management.

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